A tree kernel to analyse phylogenetic profiles
نویسندگان
چکیده
منابع مشابه
A tree kernel to analyse phylogenetic profiles
MOTIVATION The phylogenetic profile of a protein is a string that encodes the presence or absence of the protein in every fully sequenced genome. Because proteins that participate in a common structural complex or metabolic pathway are likely to evolve in a correlated fashion, the phylogenetic profiles of such proteins are often 'similar' or at least 'related' to each other. The question we add...
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Motivation: The phylogenetic profile of a protein is a string that encodes the presence or absence of the protein in every fully sequenced genome. Because proteins that participate in a common structural complex or metabolic pathway are likely to evolve in a correlated fashion, the phylogenetic profiles of such proteins are often “similar” or at least “related” to each other. The question we ad...
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Genetic distance is the number of mutation/evolutionary events between species since their divergence. The simplest way to calculate it is to count the number of difference between two sequences. However, the method, which is often refer to as hamming method, does not reflect the evolutionary history of the sequence, because not all the mutation events are recorded in the current sequences. Fig...
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Phylogenetic profiling involves the comparison of phylogenetic data across gene families. It is possible to construct phylogenetic trees, or related data structures, for specific gene families using a wide variety of tools and approaches. Phylogenetic profiling involves the comparison of this data to determine which families have correlated or coupled evolution. The underlying assumption is tha...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2002
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/18.suppl_1.s276